While Alex Rins earned the victory in the Valencia Grand Prix, Francesco Bagnaia secured his first career MotoGP championship.
Rins qualified in the second row, but led the field out of the first corner.
Lap 10 spelled trouble for eight-time world champion Marc Marquez, who crashed out of the race at Circuit Ricardo Tormo in turn eight.
Brad Binder hounded leader Rins down the stretch of the event, but was no match in the end, as Rins cruised to victory.
Binder would hang on for second, with Jorge Martin taking home the final podium position in third.
Title contender Fabio Quartararo finished fourth, ending his title hopes as Bagnaia hung onto the championship by 17 points.
Bagnaia finished ninth, giving Ducati their first riders’ title since Casey Stoner in 2007.